Endocrine Abstracts

Cancers arise through accumulation of mutations that compromise control of cell proliferation, differentiation, adhesion, invasion, angiogenesis and apoptosis. To identify targets for effective therapy, it is important to determine which lesions are needed for maintenance of the tumor. We have constructed genetically manipulated transgenic and knock-in mice to directly explore the roles of activated Myc and inactivated p53 in the genesis, progression and maintenance of neoplas...